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Home > Products > Pharmaceutical Intermediates > Glabridin Isoflavan from Licorice Root, Inhibits Inducible Nitric-Oxide Synthase
 

Glabridin Isoflavan from Licorice Root, Inhibits Inducible Nitric-Oxide Synthase

  • Glabridin Isoflavan from Licorice Root, Inhibits Inducible Nitric-Oxide Synthase
Place of Origin:
China
Brand Name:
KK
Certification:
ISO9001
Model Number:

5895635745351

Min.Order Quantity:
1g
Price:
Negotiable
Packaging Details:
discreet packing
Delivery Time:
2-3 days after receiving your payment
Payment Terms:
Bitcoin, Western Union, Money Gram, T/T
Supply Ability:
5000kg/month
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Product Description

Glabridin Isoflavan from Licorice Root, Inhibits Inducible Nitric-Oxide Synthase Mice 99.9% purity good effect
 
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(R)-4-(3,4-Dihydro-8,8-dimethyl)-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3yl)-1,3-benzenediol (glabridin), a flavonoid present in licorice extract, is known to have antimicrobial, anti-inflammatory, and cardiovascular protective activities. In the present study, we report the inhibitory effect of glabridin on nitric oxide (NO) production and inducible nitric oxide (iNOS) gene expression in murine macrophages. Glabridin attenuated lipopolysaccharide (LPS)-induced NO production in isolated mouse peritoneal macrophages and RAW 264.7 cells, a mouse macrophage-like cell line. Moreover, iNOS mRNA expression was also blocked by glabridin treatment in LPS-stimulated RAW 264.7 cells. Further study demonstrated that the LPS-induced nuclear factor (NF)-κB/Rel DNA binding activity and NF-κB/Rel-dependent reporter gene activity were significantly inhibited by glabridin in RAW 264.7 cells and that this effect was mediated through the inhibition of inhibitory factor-κB degradation and p65 nuclear translocation. Moreover, reactive oxygen species generation was also suppressed by glabridin treatment in RAW 264.7 cells. In contrast, the activity of mitogen-activated protein kinases was unaffected by glabridin treatment. In animal model, in vivo administration of glabridin increased the rate of survival of LPS-treated mice and inhibited LPS-induced increase in plasma concentrations of nitrite/nitrate and tumor necrosis factor-α. Collectively, these data suggest that glabridin inhibits NO production and iNOS gene expression by blocking NF-κB/Rel activation and that this effect was mediated, at least in part, by inhibiting reactive oxygen species generation. Furthermore, in vivo anti-inflammatory effect of glabridin suggests a possible therapeutic application of this agent in inflammatory diseases.
 
Price,company and service advantage:
1 Best service, high quality and reasonable price
2. Its customers right to choose the package (EMS, DHL, FedEx, UPS);
3. Its customers right to choose the packing way for his produccts from many recent effective packing ways
4. Specials are possible when clients order is big enough, including the discount policy;
5. Our company promise to deliver clients package to his hands safely, or well cover the total loss and reship your order;
6. Return policy: we promise we will return your money if our product don have effect
 
Our Advantages:
1.we have over 10 years experience in this aera
2.we can provide competitive price for every customer and guarantee the quality of our goods.
3.we are attention to every customers requirements and make a good relationship with them.
4.we have a long business relationship with many countries, such as canada, mexico, brazil, united kingdom, russia, germany, india, south africa, malta, egypt, armenia, australia, philippines, belgium, netherlands, denmark ect.
If you have any other questions to consult me.please not hesitate to contact me at any time.
 
1. why choose us
1. rich experience
we specialize in this filed for many years,our steriods and hormones exported to all over the world and established long friendly relations of coroperation with them.
2. great quality,purity and favorable
good quality is one of our biggest secert to success;u can get the best quality and service from us.
3. safest and fastest delivery
we have adequate stock so that we can deliver the products with 24 hours as soon as receiving the payment.fast and discreet shipment will be arranged to pass customs.
4. good package
unique ways to ship 10g to 100kg powders to your destination.we offer melting powder into liquid service and ship the liquid in special bottles.
5. great after-sales service
any questions or problems after receiving the product,pls feel free to contact us.problems would be solved immediately.
2. order guide
Q1: have your product quality been approved by third party lab
A: yes, all products are strictly tested by our qc, confirmed by qa and approved by third party lab in china, usa, canada, germany, uk, italy, france etc. so you will be assured with good quality if you choose us.
Q2: how do you treat quality complaint
A: first of all, our qc department will do strict examination of our export products by hplc, uv, gc , tlc and so on in order to reduce the quality problem to near zero. if there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: is there any discount
A: yes, for larger quantity, we always support with better price.
Q4: how long does it take to the goods arrived
A:it is depending on your location,
for small order, please expect 5-7 days by dhl,ups,tnt, fedex, ems.
for mass order, please allow 5-8 days by air, 20-35 days by sea.
Q5 do you have any reshipment policy
A: we have good after-sale service and re-shipment policy if the parcel lose.
 

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